The use of pre-notification letters as a tool to increase response rates for mail and web surveys has been widely researched and shown to have a significant impact on response rates. The same can be said for the use of non-standard mailing techniques including FedEx. However, typical study designs turn to FedEx towards the end of data collection once the sample size has decreased making its higher per mailing costs more manageable. This paper will look at the effect the use of FedEx has when used to send the pre-notification letter as compared to using it for a late reminder letter when inviting people to complete a Web-based survey. In addition to response rate differences cost effectiveness will also be measured. Although using FedEx upfront is costly, if the jump in response rates leads to significantly fewer follow-up efforts, its cost may be justified. Data will come from the third wave of the School Based Substance Use Prevention Programs Study which is sponsored by The National Institute on Drug Abuse and conducted by the Pacific Institute for Research and Evaluation and Market Strategies International.